12/21/2023 0 Comments Symptoms of pathological fatigueSARS-CoV-2, a novel β-coronavirus, is phylogenetically related to coronaviruses responsible for SARS and Middle East respiratory syndrome (MERS) (SARS-CoV and MERS-CoV, respectively). The US Centers for Disease Control and Prevention uses the term ‘post-COVID conditions’ as an umbrella term for the wide range of health consequences that are present ≥4 weeks after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Proposed guidelines from the National Institute for Health and Care Excellence, Scottish Intercollegiate Guidelines Network and the Royal College of General Practitioners, all in the UK, define ‘acute COVID-19’ as signs and symptoms of COVID-19 for up to 4 weeks ‘ongoing symptomatic COVID-19’ as signs and symptoms of COVID-19 present from 4 weeks to 12 weeks of infection and post-COVID-19 syndrome as signs and symptoms consistent with COVID-19 that are present for more than 12 weeks after infection and not attributable to alternative diagnoses 4. In the absence of a unifying disease definition, working constructs of long COVID have included the persistence of a constellation of symptoms for time periods varying from >4 weeks from symptom onset 2 to symptoms that last for more than 3 months after onset 3. As the world grapples with successive waves of infection fueled by the emergence of viral variants, in a subset of patients who recover, protracted disease symptoms, termed ‘long COVID’, ‘long-haul COVID’ or ‘post-COVID syndrome’, are being increasingly recognized. As of 15 November 2021, an estimated 254 million cases and 5.1 million deaths have been ascribed to COVID-19 1.
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